Rasthor a écrit :
Interessant:
Sur les vaccins a adénovirus, il y aurait des problemes des splicing sur l'ARNm, donc des proteines Spike incomplète qui se libèrent dans la circulation sanguine, et c'est ce qui créerait (au conditionel pour le moment) les problèmes de thromboses. Source:
https://www.nature.com/articles/d41586-021-02291-2
Citation :
But cancer researcher Rolf Marschalek at Goethe University Frankfurt in Germany and his colleagues have shown that the snippets of RNA that encode spike can be cut apart and stitched back together in different ways in human cells; some of these forms, called splice variants, can generate spike proteins that get into the blood and then bind to the surface of cells that line blood vessels10. There, they cause an inflammatory response that is also seen in some SARS-CoV-2 infections, which in severely affected people can lead to the formation of clots.
And the lower rate of clots in J&J’s vaccine compared with Oxford–AstraZeneca’s could be because the version of spike generated by the J&J vaccine was engineered to remove the sites that allow the RNA to be processed into splice variants, says Marschalek.
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Et le pre-print, avec discussion Q&A:
https://www.researchsquare.com/article/rs-558954/v1
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